Projects

Population Genetics

Association studies aim to identify genetic variations in inflammasome genes that contribute to common, complex diseases, such as diabetes, asthma, cancer, and infectious diseases

Inflammasome Investigation

Study the inflammasome pathway using in vitro assays

to detect the measurable outcomes of inflammasome formation and activation in physiologic and pathologic conditions. Methods include cytokines dosage (ELISA), caspase-1 activation (flow cytometry, western blot), immunofluorescence staining, cell death analysis.

Diagnostic Support

Funcional tests for inflammasomopathies

Fundings

FAPESP grant 2023/17878-0

Evaluation of Inflammasome Activation in Cells of Patients with Autoinflammatory Disease and Its Correlation with Individual Genetics

(2024-2026)

FAPESP grant 2021/05420-4

Inflammasome genetics as a risk factor for the clinical heterogeneity of SARS-Cov-2 infection (2022-2024)

FAPESP grant 2019/06363-4

Modulator effect of TORID on the pathological activation of inflammasome: a genetic-based approach (2019-2021)

FAPESP- University Agency of the Francophonie (AUF) grant 2015/50650-7

Charaterization of novel molecular players in the control of obesty and obesity-induced inflammasion (2017-2019)

FAPESP- grant 2015/23395-6

Immunogenetics of the inflammasome and translational study "from bed to bench and back": analysis of variations in inflammasome genes in monogenic and multifactorial autoinflammatory diseases for differential diagnosis and therapeutic applications (2016-2018)

FAPESP - grant 2013/06142-1

Genomic signature of immune response against HIV-1 and its implications for dendritic cell-based therapeutic vaccine against HIV-1 (2013-2016)